ROS-responsive hydrogel patch orchestrating macrophage reprogramming and mitochondrial protection for post-MI repair - PubMed

4 hours ago

Myocardial infarction (MI) leads to irreversible cardiomyocyte loss, oxidative stress, inflammation, and fibrotic remodeling, progressing to heart failure.
Salvianolic acid B (DB), identified via network pharmacology, is a promising therapeutic candidate for MI but has poor bioavailability.
An injectable ROS-responsive hydrogel patch was developed for localized MI repair, composed of WPI-MA and HA-NB, forming a biocompatible and adhesive network.
ROS-sensitive liposomes encapsulating DB were incorporated into the hydrogel for localized and on-demand drug release in response to oxidative stress.
In vitro studies showed the hydrogel has favorable mechanical strength, selective myocardial adhesiveness, and sustained antioxidant capacity.
In a murine MI model, the hydrogel patch attenuated fibrosis, promoted angiogenesis, and restored cardiac function.
The study presents a strategy from drug discovery to responsive delivery system construction for post-infarction cardiac repair.

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