Obesity, type 2 diabetes and cancers of the digestive system - PubMed
3 hours ago
- #digestive cancer
- #obesity
- #type 2 diabetes
- Obesity and type 2 diabetes mellitus are significant risk factors for digestive system cancers.
- Epidemiologic evidence shows increased cancer incidence and mortality linked to these conditions, with variations by sex and ethnicity.
- Mechanisms include hyperglycemia, insulin resistance, altered adipokines, gut dysbiosis, chronic inflammation, and oxidative stress.
- Most mechanistic evidence comes from non-human models, requiring cautious interpretation for human cancer risk.
- Targeted prevention strategies like weight management and glycemic control are recommended for high-risk populations.