SHMT2 deficiency disrupts transcriptional regulation through homocysteine-mediated suppression of histone lactylation in Huntington's disease models - PubMed
3 days ago
- #Epigenetics
- #Neurodegeneration
- #Metabolism
- SHMT2 deficiency is linked to Huntington's disease (HD) pathogenesis.
- SHMT2 downregulation exacerbates mHTT aggregation and MSN degeneration.
- Homocysteine accumulation from SHMT2 deficiency suppresses histone lactylation.
- SHMT2 overexpression improves motor function and reduces neurodegeneration in HD models.
- Haloperidol modulates SHMT2 expression and restores histone lactylation.