Renal macrophage TLR7 signaling in lupus nephritis: from pathogenic mechanisms to therapeutic opportunities - PubMed
4 hours ago
- #macrophages
- #lupus nephritis
- #TLR7
- TLR7 signaling in macrophages is a key driver in lupus nephritis (LN) pathogenesis.
- TLR7 activation by ssRNA in renal macrophages promotes inflammatory cytokine production and tissue damage.
- TLR7 and its downstream mediators are promising therapeutic targets for LN.
- Recent studies highlight TLR7's role in systemic lupus erythematosus (SLE) through gain-of-function mutations.
- The review focuses on macrophage biology to identify novel TLR7-modulating therapies.