The AAA-ATPase Yta4 inhibits the interaction between Ppa2 and Atg43 to promote Atg43 phosphorylation and mitophagy - PubMed
3 hours ago
- #mitophagy
- #fission yeast
- #phosphorylation
- AAA-ATPase Yta4/Msp1/ATAD1 is a quality control factor that clears mistargeted proteins on mitochondria.
- Yta4 promotes mitophagy in fission yeast by facilitating phosphorylation of the mitophagy receptor Atg43.
- Atg43 phosphorylation sites Ser32, Ser35, and Ser36 are crucial for mitophagy.
- Phosphatase Ppa2 dephosphorylates Atg43 and inhibits excessive mitophagy.
- Yta4 interacts with both Atg43 and Ppa2, inhibiting their interaction to promote Atg43 phosphorylation.
- Yta4 and Ppa2 bind to the same cytosolic region of Atg43.
- The study reveals a novel role of Yta4 in regulating mitophagy in fission yeast.