De novo design of functional nucleic acids of aptamers - PubMed
7 hours ago
- #aptamer design
- #NA-LLMs
- #functional nucleic acids
- De novo design of functional nucleic acids (FNAs) is challenging due to vast sequence space and inefficient experimental screening.
- InstructNA framework combines NA-LLMs and HT-SELEX for FNA design without relying on structural information.
- InstructNA encodes rich FNA representations and decodes sequences, enabling diverse FNA generation (e.g., transcription factor-binding DNA, protein-binding aptamers).
- Compared to HT-SELEX, InstructNA generates 100-200% more strong aptamer binders with low sequence similarity (38%).
- Demonstrates efficacy and robustness for advanced FNA design.