Artesunate Ameliorates APAP-induced Liver Injury by Promoting NEDD4L-Mediated Ubiquitination and Degradation of TXNIP - PubMed
3 hours ago
- #NEDD4L-TXNIP axis
- #liver injury
- #artesunate
- Artesunate (ART) shows protective effects in preclinical models of liver injury induced by APAP, CCl4, and Con A.
- ART binds to specific residues in the HECT domain of NEDD4L, enhancing its interaction with TXNIP.
- This interaction promotes the ubiquitination and degradation of TXNIP, alleviating liver injury.
- Overexpression of TXNIP or knockout of NEDD4L negates ART's protective effects.
- The study highlights the NEDD4L-TXNIP axis as a key player in liver injury and ART's potential clinical use.