FBR-NDs: a ferroptosis-inducing nanocomplex for targeted breast cancer therapy via immune modulation and redox-responsive drug delivery - PubMed
3 hours ago
- #Immunotherapy
- #Ferroptosis
- #Breast Cancer
- FBR-NDs are a novel ferroptosis-inducing nanocomplex designed for targeted breast cancer therapy.
- The nanocomplex was synthesized via nanoprecipitation and characterized using TEM, XPS, and FT-IR spectroscopy.
- FBR-NDs demonstrated redox-responsive drug release under acidic pH and GSH conditions.
- In vitro studies showed significant inhibition of breast cancer cell proliferation and induction of ferroptosis.
- In vivo studies in a 4T1 breast cancer mouse model confirmed reduced tumor growth and enhanced immune responses.
- FBR-NDs promoted infiltration of immune cells like dendritic cells and M1 macrophages, and activated T-cells.
- The study suggests FBR-NDs as a promising therapeutic strategy combining ferroptosis induction and immune modulation.