Polypyrrole nanozymes with cell-free DNA scavenging and ferroptosis inhibition capabilities for the treatment of acetaminophen-induced acute liver injury - PubMed
3 hours ago
- #acute liver injury
- #nanozymes
- #ferroptosis inhibition
- Polypyrrole nanozymes (PPy-Mg NPs) were synthesized for treating acetaminophen-induced acute liver injury (AILI).
- PPy-Mg NPs scavenge reactive oxygen and nitrogen species (RONS) and cell-free DNA, reducing oxidative stress.
- The nanozymes modulate biological signaling pathways like NF-κB and Nrf2-Keap1, inhibiting ferroptosis/apoptosis.
- Current treatment N-acetylcysteine (NAC) is ineffective in advanced AILI, highlighting the need for new therapies.
- PPy-Mg NPs offer metabolic rescue, necrotic debris clearance, and cell protection, extending therapeutic windows.