The Erlin1/2 complex is a dynamic scaffold for membrane microdomain assembly on the endoplasmic reticulum - PubMed
3 hours ago
- #Erlin1/2 complex
- #membrane microdomain
- #ERAD regulation
- The Erlin1/2 complex is a 26-mer cage assembly on the endoplasmic reticulum (ER) luminal leaflet.
- It forms membrane microdomains with phosphatidylinositol-binding pockets, recruiting ER proteins inside and outside the cage.
- Caging secludes cargoes from substrates or partners, adding a regulatory layer to functions like ER-associated degradation.
- Individual cages cluster to organize functional membrane microdomains of varying sizes.
- These dynamic properties regulate ER-related processes, including coronaviral replication.