Macrophage-derived legumain ameliorates excessive mechanical stress-induced ferroptosis of nucleus pulposus cells and intervertebral disc degeneration via integrin αvβ3-Hippo signaling - PubMed
3 hours ago
- #Mechanical stress
- #Ferroptosis
- #Intervertebral disc degeneration
- Macrophage-derived legumain helps reduce ferroptosis in nucleus pulposus cells caused by excessive mechanical stress.
- The study identifies integrin αvβ3-Hippo signaling as a key pathway in mitigating intervertebral disc degeneration.
- Ethical approvals were obtained from Southeast University and Zhongda Hospital for both animal and human studies.
- The authors declare no competing interests.
- References highlight the global burden of low back pain and its association with intervertebral disc degeneration.
- Funding sources include the National Natural Science Foundation of China and other institutional grants.