Female-specific Cx3cr1-driven regulation of ALS and Alzheimer's risk genes in tauopathy - PubMed
3 hours ago
- #Cx3cr1
- #Neurodegeneration
- #Tauopathy
- The study introduces Cx3cr1 haploinsufficiency into a P301S transgenic mouse model of tau pathology (PS19).
- This leads to significant transcriptional changes, involving key risk genes for ALS and Alzheimer's disease.
- Co-expression patterns among some of these risk genes suggest potential gene-gene interactions.
- The reported regulatory effects are specific to females.
- The research highlights the role of Cx3cr1 and microglia in modulating genetic risk factors for neurodegenerative diseases.