Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance - PubMed
5 hours ago
- #immune resistance
- #cancer immunotherapy
- #nanoparticles
- CYN-CDA@Alb nanoparticles target mitochondria to deplete copper, which reduces CD47 and PD-L1 expression via the mitochondria/AMPK/c-MYC pathway.
- This approach enhances cancer immunotherapy by boosting T cell killing and macrophage phagocytosis, overcoming both innate and adaptive immune resistance.
- Copper depletion nanoparticles are more effective than common chelators, requiring only 1/50 of the dosage to achieve similar effects.
- The nanoparticles also prevent increased immune resistance following radiotherapy by suppressing CD47 and PD-L1 upregulation.
- CYN-CDA@Alb presents a safer alternative to CD47/PD-L1 bispecific antibodies, avoiding on-target off-tumor immune toxicity and related adverse events.