TSPO governs bone-lipid homeostasis by redirecting BMSC differentiation via the PI3K/AKT/β-catenin pathway - PubMed
7 hours ago
- #osteoporosis
- #PI3K/AKT/β-catenin
- #BMSCs
- TSPO is identified as a key regulator in bone-lipid homeostasis, influencing BMSC differentiation via the PI3K/AKT/β-catenin pathway.
- TSPO upregulation in BMSCs from osteoporotic patients and models suppresses osteogenesis and promotes adipogenesis.
- Mechanistically, TSPO disrupts the PI3K/AKT/GSK-3β signaling axis, inhibiting β-catenin-mediated osteogenic transcription.
- AAV-9-mediated TSPO silencing in OVX mice improves bone microarchitecture and reduces marrow adiposity.
- Targeting TSPO presents a novel therapeutic strategy for osteoporosis by restoring bone formation.