Alteration of cellular representation in the central amygdala mediates stress-induced analgesia in mice - PubMed
3 hours ago
- #stress-induced analgesia
- #nociception
- #central amygdala
- Stress-induced analgesia (SIA) is an adaptive response moderated by the central amygdala (CeA).
- CeA somatostatin-expressing neurons (CeASst) specifically represent nociception, with acute stress suppressing their responses.
- Stress-induced suppression targets nociception specifically, not general salience responses.
- Corticotropin-releasing hormone-expressing CeA neurons (CeACrh) show varied activation patterns during acute stress.
- Inhibiting CeACrh during stress reduces SIA, indicating a state-dependent role in modulating nociception.
- Dorsal raphe nucleus neurons projecting to CeA are persistently activated during stress and mediate SIA via serotonin 2A receptors.