Calmodulin-like protein condensates decode PAMP-induced nuclear calcium to activate plant immunity - PubMed
3 hours ago
- #plant immunity
- #molecular condensates
- #calcium signaling
- Calmodulin-like proteins (CML49 and CML50) form molecular condensates in response to pathogen-associated molecular patterns (PAMPs).
- PAMP-induced nuclear calcium signals promote the formation of these condensates, which depend on EF-hand motifs and intrinsically disordered regions (IDRs).
- CML49 and CML50 condensates sequester WRKY11/17 transcription factors, suppressing their immune-inhibitory activity.
- This mechanism decodes nuclear calcium dynamics to activate plant immune responses by spatially silencing negative regulators.