Tyrosine kinase LYN restricts the replication and virulence of influenza A virus by directly phosphorylating viral nucleoprotein - PubMed
8 hours ago
- #influenza A virus
- #nucleoprotein phosphorylation
- #LYN kinase
- LYN kinase directly phosphorylates influenza A virus nucleoprotein at Y10/40/97 sites, inhibiting viral replication and virulence.
- Phosphorylation by LYN disrupts NP interaction with viral RNA and polymerase proteins, as well as NP oligomerization, impairing viral ribonucleoprotein complex assembly.
- NPY10/40/97F mutation increases IAV pathogenicity in mice, highlighting the critical role of these phosphorylation sites.
- LYN-specific agonist MLR-1023 shows therapeutic efficacy against IAV infection, suggesting potential for host-directed antiviral therapies.
- LYN is identified as a novel host factor restricting IAV, offering a target for drug development against drug-resistant strains.