VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity - PubMed
3 hours ago
- #Pancreatic Cancer
- #Tumor Microenvironment
- #Immunotherapy
- VISTA plays a crucial role in modulating tumor-associated macrophage (TAM) polarity in pancreatic ductal adenocarcinoma (PDAC).
- VISTA deficiency impairs tumor growth and prolongs survival in murine PDAC models.
- VISTA deficiency shifts TAMs from an immunosuppressive (SPP1+) to a pro-inflammatory (CXCL9+) phenotype.
- This shift enhances recruitment of CXCR3+ CD8+ T cells with sustained cytotoxic potential.
- VISTA-deficient TAMs show increased antigen cross-presentation, boosting CD8+ T cell response.
- Human PDAC data corroborate these immune reprogramming trends.
- VISTA inhibition is proposed as a strategy to reshape the tumor microenvironment and enhance anti-tumor immunity in PDAC.