TMPRSS2:ERG-directed radiosensitization: exploiting DNA repair rewiring in gene fusion-positive prostate cancer - PubMed
4 hours ago
- #radiotherapy
- #DNA repair
- #prostate cancer
- TMPRSS2:ERG gene fusion is a key oncogenic event in many prostate cancers.
- ERG overexpression rewires DNA repair towards a PARP1-dependent pathway, creating a dependency on PARP1.
- This dependency makes ERG-positive tumors sensitive to PARP inhibition during radiotherapy.
- The findings suggest ERG as a biomarker for precision radiotherapy in prostate cancer.
- Combined PARP inhibition and irradiation showed tumor-selective cytotoxicity in human-derived prostate cancer organoids.