Mitochondrial control of glycerolipid synthesis by a PEP shuttle - PubMed
3 hours ago
- #metabolic-disorders
- #mitochondria
- #glycerolipid-synthesis
- Mitochondria provide metabolites like phosphoenolpyruvate (PEP) for cell-specific needs.
- SLC25A35 regulates mitochondrial PEP efflux and glyceroneogenesis in lipogenic cells.
- PEP transport by SLC25A35 is pH gradient-dependent.
- Loss of SLC25A35 in adipocytes impairs glycerolipid synthesis by reducing glycerol-3-phosphate conversion.
- Hepatic inhibition of SLC25A35 in obese mice improves glucose homeostasis and reduces steatosis.
- Mitochondria facilitate glycerolipid synthesis via SLC25A35, offering a target to limit metabolic disorders.