SIRT6 Ameliorates Atherosclerosis by Inhibiting M1 Macrophage Polarisation Through Deacetylated-TLR4 - PubMed
4 days ago
- #macrophage polarization
- #SIRT6
- #atherosclerosis
- SIRT6 plays a protective role in atherosclerosis (AS) by inhibiting M1 macrophage polarization.
- SIRT6 is downregulated in AS mouse models and LPS-induced macrophages.
- Overexpression of SIRT6 reduces plaque size and blood lipid levels in AS models.
- SIRT6 inhibits M1 macrophage polarization by deacetylating TLR4, thereby downregulating its protein levels.
- TLR4 overexpression reverses the inhibitory effect of SIRT6 on M1 macrophage polarization.
- The study suggests SIRT6 as a potential therapeutic target for AS by modulating macrophage polarization.