Plasma p-tau217 and APOE genotype: Prodromal Alzheimer's disease staging - PubMed
a day ago
- #Alzheimer's disease
- #APOE genotype
- #plasma biomarker
- Plasma p-tau217 and APOE ε4 genotype are used to identify individuals at high risk for dementia.
- The study involved 400 cognitively normal older adults with vascular risk factors from the rrAD clinical trial.
- Plasma p-tau217 levels were 57% higher in individuals with at least one APOE ε4 allele.
- P-tau217 levels increased with age, were higher in males, and negatively correlated with brain volume measures.
- The findings suggest brain volume shrinkage in males is related to elevated p-tau217 levels.
- APOE genotyping is important for clinical practice involving p-tau217 quantification.