AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling - PubMed
2 months ago
- #Lipid Remodeling
- #Immunotherapy
- #Ferroptosis
- AGPAT3通过增强肿瘤细胞对IFNγ介导的铁死亡的敏感性发挥抑癌作用
- IFNγ激活IRF1信号通路进而上调AGPAT3表达，诱导脂质重塑
- 脂质重塑增加多不饱和醚磷脂水平，从而提升铁死亡敏感性
- AGPAT3缺失会损害IFNγ介导的体外和体内肿瘤清除效应
- 接受免疫检查点抑制剂治疗的患者中，AGPAT3高表达与更强的免疫激活和更长生存期相关
- IFNγ-IRF1-AGPAT3信号轴是通过促进铁死亡实现抗肿瘤的关键机制
- 将铁死亡驱动模型预测与AGPAT3靶向治疗相结合可能提升免疫检查点抑制剂疗效