CDKL5 modulates the plasticity of excitatory synapses via liquid-liquid phase separation - PubMed
6 days ago
- #CDKL5
- #synaptic plasticity
- #liquid-liquid phase separation
- CDKL5通过液-液相分离（LLPS）调控兴奋性突触可塑性
- CDKL5与PSD95形成共凝聚体，组织突触成分并招募Kalirin7促进树突棘增大
- CDKL5致病突变会损害LLPS功能，证实相分离缺陷与CDKL5缺乏症（CDD）存在关联
- 该研究揭示LLPS是突触重塑和突触后致密区（PSD）结构重组的关键机制