Hasty Briefsbeta

双语

Bie-Jia-Jian Pill: Inhibiting Tumor Glycolysis and Promoting CD8+ Cell-Mediated anti-tumor Immunity by Targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in Hepatocellular Carcinoma - PubMed

2 months ago
  • #Traditional Medicine
  • #Immunotherapy
  • #Hepatocellular Carcinoma
  • 鳖甲煎丸(BJJP)通过抑制肝细胞癌(HCC)中的Warburg效应增强抗肿瘤免疫力
  • 该药物可抑制HCC细胞增殖、生长和迁移,同时促进细胞凋亡并降低PD-L1表达
  • 通过增强CD8+ T细胞毒性和肿瘤浸润,与PD-L1阻断疗法产生协同增效作用
  • 靶向HIF-1α-PI3K/AKT/mTOR轴重编程肿瘤糖酵解,减少乳酸蓄积和CD8+ T细胞耗竭
  • 抑制NF-κB活化并下调CCL20,缓解其对CD8+ T细胞的抑制作用
  • 联合免疫治疗可通过调节肿瘤微环境显著改善疗效