Globo H ceramide confers chemoresistance and poor prognosis to advanced gallbladder cancer via A2AR/cAMP/PKA pathway - PubMed
2 months ago
- #immunotherapy
- #chemoresistance
- #gallbladder-cancer
- Globo H神经酰胺(GHCer)与晚期胆囊癌(GBC)化疗耐药及不良预后相关
- GHCer通过A2AR/cAMP/PKA通路促进吉西他滨耐药(GR),导致ABCG2表达上调
- 高Globo H表达与吉西他滨治疗的GBC患者较短生存期显著相关
- 抗Globo H抗体(mAb VK9)或疫苗(OBI-833/OBI-821)在模型中可逆转GR并增强吉西他滨疗效
- OBI-833/821在TAA模型中诱导免疫应答,减少Foxp3+调节性T细胞并增加CD161+ NK细胞
- 靶向Globo H可能改善GBC患者的化疗应答