Hepatitis B Virus Promotes Hepatocellular Carcinoma Progression by Disrupting NSUN2/YBX1-mediated m5C Modification of PTEN mRNA - PubMed
2 months ago
- #RNA Methylation
- #Hepatitis B Virus
- #Hepatocellular Carcinoma
- HBV通过破坏PTEN mRNA的m5C修饰促进肝细胞癌（HCC）进展
- HBV降低PTEN mRNA的m5C修饰，关键位点为chr10:89717756
- NSUN2（写入酶）和YBX1（读取器）以m5C依赖方式稳定PTEN mRNA，而HBV破坏这一机制
- 过表达NSUN2或YBX1可抑制HBV驱动的癌细胞增殖、迁移和侵袭
- HBV小表面抗原（HBsAg）和X蛋白（HBx）下调NSUN2与YBX1，从而抑制PTEN
- 在HBV转基因小鼠、感染肝细胞及临床HCC样本中均观察到HBV相关的NSUN2表达降低
- NSUN2/YBX1/PTEN信号轴是HBV相关HCC的潜在治疗靶点