Alisol B as a novel inhibitor of TβRs suppresses the growth and metastasis of non-small cell lung cancer by inhibiting TGF-β-induced epithelial-mesenchymal transition - PubMed
12 days ago
- #non-small cell lung cancer
- #epithelial-mesenchymal transition
- #TGF-β receptors
- Alisol B (ALB) 抑制肺腺癌细胞中TGF-β1诱导的增殖、迁移、侵袭和上皮-间质转化（EMT）。
- ALB直接结合TGF-β受体（TGFβR1和TGFβR2）的ATP结合位点，促进TGFβR2降解并抑制下游信号通路。
- 体内研究表明，ALB在非小细胞肺癌（NSCLC）小鼠模型中能抑制肿瘤生长和肺转移。