Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke - PubMed
2 months ago
- #immunometabolism
- #stroke
- #neuroinflammation
- Ly6C高表达单核细胞在卒中后继发性神经炎症中起关键作用
- 缺氧诱导蛋白2(HIG2)介导Ly6ChighLy6Glow单核细胞的代谢适应
- HIG2通过Hif1α依赖性调控胆碱激酶α促进磷脂酰胆碱合成
- HIG2启动脂代谢重编程,诱导单核细胞向抗炎表型转化
- 重组HIG2蛋白鼻内给药可改善卒中后神经功能预后
- 靶向HIG2或成为减轻卒中后神经炎症的新型免疫代谢策略