ACSS2 maintains oligodendrocyte progenitor cell pool and is required for myelination during development and aging - PubMed
2 months ago
- #ACSS2
- #Myelination
- #Aging
- ACSS2对维持发育和衰老过程中少突胶质前体细胞（OPC）库及髓鞘形成至关重要
- 衰老会导致OPCs数量减少（尤其是高表达Acss2的细胞群），进而影响髓鞘形成功能
- ACSS2缺失会造成OPC群体缩减、髓鞘生成缺陷、髓鞘维持障碍，并加剧年龄相关的认知缺陷
- ACSS2通过介导H4K12和H3K27乙酰化增强Gria2表达，该机制对OPC增殖具有关键作用
- 补充ACSS2底物乙酸可维持OPC数量、促进损伤后再髓鞘化，并改善老年小鼠认知功能