Macrophage Gsα promotes NLRP3 stability and its intervention attenuates abdominal aortic aneurysm in male mice - PubMed
11 days ago
- #macrophage
- #abdominal aortic aneurysm
- #NLRP3 inflammasome
- 巨噬细胞特异性Gsα缺陷可延缓雄性小鼠腹主动脉瘤（AAA）的进展。
- Gsα与NLRP3相互作用，通过防止NLRP3泛素化和降解促进炎症小体激活。
- 递送Gsα siRNA的脂质纳米颗粒可抑制NLRP3表达并减少体内AAA进展。