MST1 promotes microglial pyroptosis and neuroinflammation in alzheimer's disease by regulating the novel DPP8/NLRP1/Caspase-1/GSDMD-N axis - PubMed
3 months ago
- #Alzheimer's disease
- #Microglia
- #Neuroinflammation
- MST1促进阿尔茨海默病(AD)中小胶质细胞焦亡和神经炎症的发生
- MST1通过调控DPP8/NLRP1/Caspase-1/GSDMD-N轴加速AD病程进展
- 在5xFAD小鼠模型中敲低MST1可改善认知缺陷并减轻神经炎症
- MST1基因沉默抑制小胶质细胞活化和焦亡,从而缓解神经免疫炎症
- 靶向抑制MST1被提出作为阻断AD进展的治疗新策略