KANK4 Regulates CXCL16 Glycosylation Through TMEM260 to Modulate Microglial Activation in Sepsis-associated Encephalopathy - PubMed
2 months ago
- #Microglial Activation
- #Neuroinflammation
- #Sepsis-associated Encephalopathy
- SAE小鼠海马区及LPS诱导的小胶质细胞中KANK4表达下调
- KANK4下调与小胶质细胞过度活化及促炎细胞因子（IL-1β、IL-6、TNF-α）升高相关
- 海马区过表达KANK4可改善SAE小鼠认知功能并减轻神经元损伤
- KANK4通过结合TMEM260 mRNA的3'UTR增强其稳定性，抑制CXCL16糖基化及表达
- 过表达TMEM260可降低CXCL16水平及神经炎症，而过表达CXCL16会逆转TMEM260的神经保护作用
- KANK4-TMEM260-CXCL16轴是调控小胶质细胞活化的关键通路，为SAE治疗提供新靶点