tRF-1432 orchestrates RBMS1-IMPDH2 regulatory control to drive purine-dependent chemoresistance in breast cancer - PubMed
2 months ago
- #tRF-1432
- #Chemoresistance
- #Breast cancer
- tRF-1432在化疗耐药乳腺癌组织及细胞系中表达上调
- tRF-1432通过促进肿瘤细胞存活并抑制凋亡增强对阿霉素的耐药性
- tRF-1432与RBMS1相互作用,削弱其对IMPDH2 mRNA的 destabilization 作用,导致IMPDH2表达增加
- IMPDH2表达上调促进嘌呤代谢重编程,提高GTP水平并维持生存信号传导
- 霉酚酸(MPA)对IMPDH2的药理抑制可在体外和体内逆转化疗耐药性
- tRF-1432/RBMS1/IMPDH2轴是克服乳腺癌化疗耐药的潜在治疗靶点