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Multifunctional copper-based nanoparticles potentiate colorectal cancer immunotherapy via synergistic metabolic remodeling and cGAS-STING pathway activation - PubMed

2 months ago
  • #immunotherapy
  • #colorectal-cancer
  • #nanoparticles
  • 多功能铜基纳米颗粒(BR@CuM@CM)通过靶向代谢和免疫通路增强结直肠癌免疫治疗
  • BR@CuM@CM整合STING激动剂SR-717与糖酵解抑制剂3-BP,协同调控肿瘤微环境
  • 该纳米颗粒实现肿瘤特异性富集,并在谷胱甘肽响应下释放药物,激活STING通路并产生活性氧
  • 3-BP抑制乳酸生成,促使巨噬细胞复极化为M1表型,减少Treg细胞浸润,增强免疫应答
  • 与抗PD-1联用时,BR@CuM@CM显著抑制肿瘤生长和转移,将'冷肿瘤'转化为'热肿瘤'