Targeted inhibition of Nrf2 potentiates antitumor immunity and enhances the efficacy of immunotherapy in hepatocellular carcinoma - PubMed
2 months ago
- #Nrf2 inhibition
- #Immunotherapy
- #Hepatocellular Carcinoma
- 靶向抑制Nrf2可增强抗肿瘤免疫并提高肝细胞癌（HCC）免疫治疗效果
- 特异性Nrf2抑制剂布鲁萨托（BRU）通过下调肿瘤细胞PD-L1、上调MHC-I，促进CD8+T细胞浸润
- Nrf2抑制联合抗PD-1抗体或CAR-T细胞治疗可显著提升HCC体内治疗效果
- 该研究提出阻断Nrf2信号通路可作为克服免疫治疗耐药、提高HCC应答率的新策略