Targeting WTAP sensitizes hepatocellular carcinoma to sorafenib by inhibiting the ERK signaling pathway - PubMed
2 months ago
- #ERK pathway
- #Sorafenib resistance
- #Hepatocellular carcinoma
- 靶向WTAP通过抑制ERK信号通路使肝细胞癌（HCC）对索拉非尼敏感
- WTAP在HCC组织中表达上调，与肿瘤进展和不良临床预后相关
- 敲低WTAP可增强HCC细胞在体外对索拉非尼的敏感性
- WTAP激活ERK信号通路，导致索拉非尼耐药
- WTAP敲低联合索拉非尼治疗可抑制小鼠模型中的肿瘤进展并提高生存率
- 该研究提出靶向WTAP作为提高索拉非尼在HCC中疗效的新策略