Qigui didang decoction alleviates renal injury in a diabetic kidney disease model with metabolic memory features: association with ferroptosis and the SIRT1/Nrf2 pathway - PubMed
2 months ago
- #Diabetic Kidney Disease
- #Ferroptosis
- #SIRT1/Nrf2 Pathway
- 芪归抵当汤(QGDD)缓解具有代谢记忆特征的糖尿病肾病(DKD)模型肾损伤
- 研究揭示QGDD通过SIRT1/Nrf2信号通路调控铁死亡的作用机制
- QGDD干预降低尿蛋白排泄并改善肾功能指标(BUN、Scr、Cys-C、β2-MG)
- 中剂量QGDD显著降低氧化应激标志物(Fe2+、MDA)并提升抗氧化活性(GSH、SOD)
- QGDD激活SIRT1/Nrf2通路,上调Nrf2、HO-1和GPX4,同时抑制AGEs和铁蛋白沉积
- 中剂量QGDD组展现最佳治疗效果,凸显剂量优化的重要性
- QGDD的多靶点效应为中药复方治疗DKD提供理论基础