Hasty Briefsbeta

双语

PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer by upregulating AIFM2 - PubMed

3 months ago
  • #metastasis
  • #prostate cancer
  • #ferroptosis
  • PDHA1增强抗失巢凋亡前列腺癌细胞对铁死亡的抵抗能力
  • 核内PDHA1通过增加PPARA启动子区域的H3K9乙酰化修饰,上调PPARA和AIFM2的表达
  • AIFM2表达上调可抑制铁死亡,促进前列腺癌细胞存活和转移
  • 转移性前列腺癌患者中PDHA1表达升高,提示其作为潜在治疗靶点