PAK5-Mediated Suppression of β-Hydroxybutyrate Production Promotes Breast Cancer Metastasis and Can Be Overcome with Ketogenic Diet - PubMed
2 months ago
- #breast cancer
- #ketogenic diet
- #metastasis
- PAK5通过抑制β-羟基丁酸（β-HB）生成促进乳腺癌转移
- 乳腺癌患者（尤其转移病例）体内β-HB水平显著降低
- PAK5通过磷酸化酮体生成关键酶HMGCS2抑制β-HB合成
- HMGCS2的Ser138和Ser311位点磷酸化导致其稳定性与活性下降
- PAK5高表达与乳腺癌转移及不良预后显著相关
- 生酮饮食（KD）或补充β-HB可逆转PAK5驱动的转移效应
- HMGCS2低表达与β-HB合成减少共同促进淋巴结转移
- PAK5-HMGCS2信号轴成为乳腺癌转移治疗的潜在靶点