Targeting MSR1+ tumor-associated macrophages enhances the therapeutic efficacy of anti-PD-L1 in Hepatocellular carcinoma by suppressing NF-κB pathway activation - PubMed
2 months ago
- #Tumor-associated macrophages
- #Immunotherapy
- #Hepatocellular carcinoma
- MSR1+肿瘤相关巨噬细胞(TAMs)通过促进免疫抑制性肿瘤微环境在肝细胞癌(HCC)中发挥重要作用
- MSR1+ TAMs高水平表达与HCC患者不良预后显著相关
- MSR1通过激活NF-κB通路增强IL-6分泌，导致髓系来源抑制细胞(MDSCs)募集并降低CD8+ T细胞功能
- 临床前模型中联合抑制MSR1与PD-L1比单一治疗能更显著抑制肿瘤生长
- 靶向MSR1+ TAMs可克服抗PD-L1疗法耐药性，为HCC提供新型免疫治疗策略