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Single-Nucleus Transcriptomics Reveals Microglial State Transitions and Astrocytic Trajectory Divergence During Glial Remodeling Induced by Intracortical Electrode Implantation - PubMed

2 months ago
  • #bioinformatics
  • #neuroscience
  • #neuroinflammation
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  • 发现病理性小胶质细胞亚群(以Gpnmb、SPP1、CD63为标记物)和瘢痕相关星形胶质细胞亚型(特征性表达Mctp1、Lrrc7)
  • 神经元通过CX3CL1-CX3CR1信号通路和PTN-ALK/Ptpprz1相互作用调控小胶质细胞极化及星形胶质细胞增生
  • 研究结果为提升神经接口长期生物相容性提供了新机制见解