Machine learning reveals targets of Gnaphalium hypoleucum DC. flavonoids against rheumatoid arthritis through gut microbiota and anti-inflammation - PubMed
2 months ago
- #gut microbiota
- #machine learning
- #rheumatoid arthritis
- 机器学习鉴定出Gnaphalium hypoleucum DC.黄酮类化合物（GHTFs）治疗类风湿性关节炎（RA）的关键靶点
- GHTFs与穗花杉双黄酮（AF）通过抑制IL-17、TNF-α和NF-κB通路在体外展现抗炎效果
- 动物实验中GHTFs使关节炎评分降低40%以上，降低TNF-α和IL-1β水平，并改善肠道菌群平衡
- GHTFs显著增加有益乳杆菌属数量，减少促炎肠道细菌，助力免疫调节
- 分子对接证实AF与MMP9、MMP13、TOP2A和ALOX5等核心靶点能形成稳定结合