A NIR-Ⅱ Fluorescent Probe for Real-Time Visualization and Early Assessment of Responses to CDK4/6 Inhibitors in Breast Cancer - PubMed
2 months ago
- #NIR-II imaging
- #breast cancer
- #CDK4/6 inhibitors
- 开发一种NIR-II荧光探针（HSA-ICi）用于乳腺癌CDK4/6抑制剂响应的实时可视化
- HSA-ICi靶向CDK4/6-cyclin D复合物，具有高肿瘤蓄积性，可实现早期药效动力学响应监测
- 治疗后一周即检测到肿瘤荧光信号显著减弱，早于肿瘤体积变化
- 早期信号降低与肿瘤组织中pRB和Ki-67表达减少相关
- 该探针可区分CDK4/6抑制剂敏感型与耐药型肿瘤，有助于早期耐药识别
- 有望为HR+/HER2-乳腺癌患者提供及时治疗调整依据