Single-cell RNA sequencing and spatial transcriptomics reveal heterogeneity and key subgroups in ovarian cancer: HOXA1 identified as a potential therapeutic biomarker - PubMed
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- 采用单细胞RNA测序（scRNA-seq）和空间转录组学（ST）技术研究卵巢癌（OC）
- 鉴定出关键肿瘤亚群C4 SAA1+肿瘤细胞，主要存在于未经治疗的OC患者中
- 确定HOXA1是OC的关键转录因子（TF）和潜在治疗生物标志物
- 开发了预后模型SAA1+肿瘤细胞风险评分（STRS）用于评估风险分组
- 该研究为理解OC异质性、预后及潜在治疗靶点提供了新见解