Oncolytic virus OH2 induces PD-L1 upregulation via NF-κB signaling and synergizes with anti-PD-L1 therapy in prostate cancer through a targeted extracellular vesicle delivery system - PubMed
3 months ago
- #Immunotherapy
- #Prostate Cancer
- #Oncolytic Virus
- 溶瘤病毒OH2能有效杀灭前列腺癌细胞，但会通过NF-κB信号通路上调PD-L1表达，导致适应性免疫抵抗
- 研究团队开发了新型靶向递送系统OH2@RRA-AP-EVs，可增强肿瘤靶向性并实现ROS触发的PD-L1阻断
- 静脉注射OH2@RRA-AP-EVs相较游离OH2使肿瘤生长抑制率提高70%，并显著增强CD8+ T细胞浸润
- 该研究揭示了OH2诱导PD-L1表达的机制，并为前列腺癌病毒免疫治疗提供了多功能递送平台