Human umbilical cord-derived mesenchymal stem cell exosomes ameliorate hepatocyte ferroptosis and sepsis-associated liver injury by restoring iron homeostasis in hepatocytes - PubMed
2 months ago
- #sepsis
- #liver injury
- #ferroptosis
- 人脐带间充质干细胞外泌体（HUMSCs-Exo）能够减轻肝细胞铁死亡及脓毒症相关肝损伤（SALI）
- HUMSCs-Exo通过调控FPN、xCT、GPX4、FTH1、ACSL4和TFRC等关键蛋白恢复肝细胞铁稳态
- 这些外泌体可降低细胞内脂质过氧化和不稳定铁积累，从而保护肝脏免受损伤
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