Gut Microbiota Dysbiosis and Metabolite Imbalance Mediate Diabetic Kidney Disease Inflammation: Mechanisms and Intervention Strategies Targeting Gut-Kidney Axis and NF-κB/NLRP3 Pathways - PubMed
2 months ago
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- #diabetic kidney disease
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- DKD的特征是产短链脂肪酸菌减少而致病性变形菌增加，导致有害代谢物积累
- 这种失衡会损害肠道屏障、促进内毒素移位，并激活NF-κB和NLRP3炎症小体通路
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- 临床获益包括降低尿白蛋白肌酐比(UACR)、改善估算肾小球滤过率(eGFR)及减少促炎细胞因子(IL-1β、TNF-α)