IL 15 enhances preclinical efficacy of anti-core 1 O-glycans monoclonal antibody NEO-201 against human endometrial and ovarian cancer - PubMed
2 months ago
- #immunotherapy
- #gynecological-cancer
- #NK-cells
- IL-15增强单克隆抗体NEO-201对抗子宫内膜癌和卵巢癌的疗效
- NEO-201靶向癌细胞上的核心1 O-聚糖，通过ADCC和CDC介导杀伤作用
- NEO-201与IL-15联用可增强NK细胞活性，在体外实验中提升ADCC效果
- 该联合疗法使卵巢癌小鼠的生存期得到适度延长
- 未来潜力包括将NEO-201、IL-15与CAR-NK细胞疗法进行三联组合