Neutralization of acyl-CoA-binding protein attenuates glucocorticoid-mediated suppression of cancer immunosurveillance - PubMed
2 months ago
- #immunotherapy
- #cancer
- #glucocorticoids
- 糖皮质激素(GCs)通过ACBP/DBI关键介质抑制抗癌免疫应答
- 在小鼠模型中,皮质酮(CORT)加速肿瘤进展并降低免疫原性化疗和PD-1阻断疗效
- 通过基因敲除或单克隆抗体中和ACBP/DBI,能以T细胞依赖性方式恢复抗肿瘤免疫力
- CORT诱导树突细胞中Tsc22d3表达,损害I型干扰素信号和抗原呈递,该效应可被ACBP/DBI中和逆转
- ACBP/DBI中和疗法有望成为对抗癌症中GC诱导免疫抑制的潜在治疗策略